How to explore functional data

During the Western Brainhack 2022, we built a Functional Atlas Explorer. The web-based app allows the user to explore functional regions in the cerebellum. Selecting a cerebellar regions gives a task profile (which functions is this region involved in?) and a connectivity profile (which cortical regions are functionally connected to this cerebellar region?).

Mapping cerebellar function across cognitive domains

In recent years, the cerebellum has been increasingly implicated in both cognition and clinical conditions. These findings views of the cerebellum as a purely motor structure. By reviewing recent advances in mapping cerebellar function social, …

Cerebellar GABA change during visuomotor adaptation relates to adaptation performance and cerebellar network connectivity

Cerebellar anodal tDCS does not facilitate visuomotor adaptation or retention

Cerebellar GABA change during visuomotor adaptation relates to adaptation performance and cerebellar network connectivity: A Magnetic Resonance Spectroscopic Imaging study.

Motor adaptation is crucial for performing accurate movements in a changing environment and relies on the cerebellum. Although cerebellar involvement has been well characterized, the neurochemical changes in the cerebellum that underpin human motor adaptation remain unknown. We used a novel Magnetic Resonance Spectroscopic Imaging (MRSI) technique to measure changes in the major inhibitory neurotransmitter γ-aminobutyric acid (GABA) in the human cerebellum during visuomotor adaptation. Participants used their right hand to adapt to a rotated cursor in the scanner, compared with a control task requiring no adaptation. We were able to spatially resolve adaptation-driven GABA changes at the cerebellar nuclei and in the cerebellar cortex in the left and the right cerebellar hemisphere independently and found that simple movement of the right hand increases GABA in the right cerebellar nuclei and decreases GABA in the left. When isolating adaptation-driven GABA changes, we found an increase in GABA in the left cerebellar nuclei and a decrease in GABA in the right cerebellar nuclei during adaptation. Early adaptation-driven GABA change in the right cerebellar nuclei correlated with adaptation performance: Participants showing greater GABA decrease adapted better, suggesting that this early GABA change is behaviourally relevant. Early GABA change also correlated with functional connectivity change in a cerebellar network: Participants showing a greater decrease in GABA also showed greater strength increase in cerebellar network connectivity. These results were specific to GABA, specific to adaptation and specific to the cerebellar network. This study provides the first evidence for plastic changes in cerebellar neurochemistry during a motor adaptation task. Characterising these naturally occurring neurochemical changes may provide a basis for developing therapeutic interventions to facilitate neurochemical changes in the cerebellum that can improve human motor adaptation.

GABA in primary motor cortex and cerebellum underpins adaptation and retention


Cerebellar Structure and Function


Lecture introducing cerebellar structure and function. Part of the Motor Systems Module of the MSc Neuroscience in Oxford.

Linking neurochemistry, functional connectivity and behaviour in human motor adaptation

GABA and human motor adaptation

At the Dartmouth fMRI Brownbag Series, I was invited to present my PhD work, in which I used multimodal imaging to elucidate the role of GABA in human motor adaptation.